Water soluble CBD, how does it work and what is the best technology? Liposome encapsulation or Nanotechnology?Entourage21
The risks of nanotoxicity to human health and the environment
The widespread use of manufactured nanomaterials in consumer, industrial and agricultural products will dramatically increase our exposure. Study of the negative health impacts of exposure to very small particles in air pollution, coal and silica dust, welding fumes and asbestos is informing the emerging field of nanotoxicology. Much more research is needed to understand the health risks of nanomaterials already used in hundreds of products world-wide. New technologies need far more research before being allowed to be used in the food chain. It is our belief that nanotechnology should not be used in the CBD industry. Already we are seeing many products, including water and tinctures in the market. We are yet to see any safety research on these products.
Why do nanomaterials present greater toxicity risks than larger particles and materials?
Smaller particles have a greater reactive surface area than larger particles, are more chemically reactive and produce greater numbers of reactive oxygen species that include free radicals. This is one of the primary mechanisms of nanoparticle toxicity; it may result in oxidative stress, inflammation, and consequent damage to proteins, membranes and DNA. Nanomaterials are able to cross biological membranes and access cells, tissues and organs that larger sized particles normally cannot. Nanomaterials can gain access to the blood stream following inhalation or ingestion.
Nanomaterials have proved toxic to human tissue and cell cultures. Resulting in increased oxidative stress, inflammatory cytokine production and cell death. Studies demonstrate the potential for nanomaterials to cause DNA mutation. It could induce major structural damage to mitochondria, even resulting in cell death. Size is clearly a key factor in determining the potential toxicity of a particle. However it is not the only important factor. Other properties of nanomaterials that influence toxicity include: chemical composition, shape, surface structure, surface charge. Aggregation and solubility, and the presence of “functional groups” of other chemicals.
To read the full article click here https://www.env-health.org/IMG/pdf/17-_NANOTECHNOLOGY_AND_HEALTH_RISKS.pdf
We found the risk too great to use nanotechnology when developing a water soluble based CBD product. After much research we came across liposome encapsulation. This gave us the confidence to move ahead with this delivery system to use with our water soluble CBD. This is quite important to us as we value health above all else. Most water soluble CBD products on the market are made with nanotechnology which is worrisome in a highly unethiclal market.
How liposome encapsulation works
Transporting supplements through the small intestine and into the bloodstream. This technology has been utilised since the 1960s. It’s used as an effective method for delivering drugs, nutrients, or genetic material into the body. With the vast therapeutic potential of CBD for many health conditions, cbDNA utilise the technological innovation of Liposomal Encapsulation. We optimise the active absorption of CBD with our water soluble product.
What are Liposomes?
What makes liposomes unique and effective carriers is. They can safely transport ingredients through the gastrointestinal tract into target areas of the body. Liposomes are very safe since they are non-toxic and non-immunogenic.
The Advantages of Liposomes for CBD Delivery
Unlike other drug delivery methods, liposomes transport ingredients past the intestinal membrane to specific tissues. The ingredients inside these tiny spheres are fully protected against degradation as they reach the target areas in the body. The bioavailability of nutrients delivered via liposomes is therefore particularly high.
Liposomes are highly biodegradable, unlike other carriers sometimes employed for drug delivery. There are no side effects to liposomes or their consumption.
Liposomes allow individuals to receive the optimal amount of Water soluble CBD technology with each dose. This presents a more stable and consistent delivery of CBD, directly to the cells that need it.
Liposome encapsulation gives a delivery system that allows the taker to absorb up to 100% of the CBD.
The advantage of Water soluble CBD technology in this form is you can add it to drinks, sweets and other products. The vast majority of products on the market are using CBD oil which makes them a gimmick. Water soluble CBD gives people the chance to add a product to their drinks and sweets which will allow the user to benefit from the CBD in them.
Water soluble beer
We have developed a low alcohol, gluten free CBD beer with 8mg of CBD per bottle. https://www.hopwellbrewco.co.uk/ The flavour profile of hop and hemp are complimentary. Both species of plant come from the same family. The terpenes within the two plants are very similar and work well together when mixed to give a citrus flavour. We are the first beer to use water soluble CBD, all the others on the market are using CBD oil. The implications of this for the other brands is theirs will have a residue. The oil will separate from the beer and sit on the top. This is not ideal when you are serving a product which will be drink from a glass.
The potential of water soluble
Moving forward in the world of Water soluble CBD technology, water soluble gives us the chance to do away with CBD. We have a product that has a proven ability to deliver CBD into the body with accuracy rather than guesswork. With liposome encapsulation, we can absorb near 100% of the CBD. With oil you have to hold it under your tongue for 3 minutes to absorb around 20% of the product. Per milligram water soluble is more expensive. When you break it down however, it works out cheaper, 500mg would be the equivalent of 2500mg of an oil. A 500mg of water soluble CBD is £49.99, a 2500mg oil would cost around £130. Not only is the water soluble more accurate, it is more cost effective. In our opinion, water soluble is the future of CBD, it allows the market to give customers confidence.
A one size fits all product could be sold by all companies to take away the large scale confusion in the market. Many customers do not understand why there are so many different strengths and percentages of CBD. The market is flooded with jargon, nearly everyone we speak to has no clue where to start. All of this could be ended overnight, with an agreed upon strength that everyone sticks to. This doesn’t mean that people couldn’t add their own spin. It is possible to use additives such as curcumin or vitamin D for instance to market towards a certain type of customer or market. The possibility to change the market and become more transparent is much needed. By March 2021, the FDA are making a ruling on what can and cannot be sold, we hope water soluble is a flagship product.